Mechanisms controlling Th17 cytokine expression and host defense.

  title={Mechanisms controlling Th17 cytokine expression and host defense.},
  author={Jeremy P. McAleer and Jay K Kolls},
  journal={Journal of leukocyte biology},
  volume={90 2},
Th17 cells contribute to mucosal immunity by stimulating epithelial cells to induce antimicrobial peptides, granulopoiesis, neutrophil recruitment, and tissue repair. Recent studies have identified important roles for commensal microbiota and Ahr ligands in stabilizing Th17 gene expression in vivo, linking environmental cues to CD4 T cell polarization. Epigenetic changes that occur during the transition from naïve to effector Th17 cells increase the accessibility of il17a, il17f, and il22 loci… CONTINUE READING