Mechanisms contributing to the dopamine induction of crawl-like bursting in leech motoneurons.

@article{Crisp2012MechanismsCT,
  title={Mechanisms contributing to the dopamine induction of crawl-like bursting in leech motoneurons.},
  author={Kevin M. Crisp and Brian R Gallagher and Karen A Mesce},
  journal={The Journal of experimental biology},
  year={2012},
  volume={215 Pt 17},
  pages={3028-36}
}
Dopamine (DA) activates fictive crawling behavior in the medicinal leech. To identify the cellular mechanisms underlying this activation at the level of crawl-specific motoneuronal bursting, we targeted potential cAMP-dependent events that are often activated through DA(1)-like receptor signaling pathways. We found that isolated ganglia produced crawl-like motoneuron bursting after bath application of phosphodiesterase inhibitors (PDIs) that upregulated cAMP. This bursting persisted in salines… CONTINUE READING
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