Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration.

@article{Hotchkiss2003MechanismsBW,
  title={Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration.},
  author={Kylie A. Hotchkiss and Anthony W Ashton and Robert S. Klein and Michelle L. Lenzi and Geng Hui Zhu and Edward L. Schwartz},
  journal={Cancer research},
  year={2003},
  volume={63 2},
  pages={527-33}
}
The angiogenic factor thymidine phosphorylase (TP) is highly expressed in many human solid tumors, and the level of its expression is associated with tumor neovascularization, invasiveness, and metastasis and with shorter patient survival time. TP promotes endothelial cell (EC) migration in vitro and angiogenesis in vivo, and these have been linked to its enzymatic activity. The mechanism by which TP stimulates EC migration was investigated using human umbilical vein ECs (HUVECs). TP induced… CONTINUE READING
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Endothelial cell migration stimulated by thymidine phosphorylase is mediated via the integrins 5 1 and V 3

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1 Excerpt

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