Mechanisms by which leukocytes emigrate and induce tissue destruction

  title={Mechanisms by which leukocytes emigrate and induce tissue destruction},
  author={Robert J. Perper},
  journal={Agents and Actions},
Chronic inflammatory reactions are characterized by emigration of leukocytes to chemotactic stimuli and the subsequent release of intracellular enzymes which propogate the imflammatory reaction and causes tissue injury. The adoptive transfer of isologous51Cr labeled leukocytes was used as a model to dissect the cellular mechanisms involved in cell accumulation to the site of immune complex or complement mediated imflammatory reactions. An intact microtubular system was necessary only for… CONTINUE READING
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