Mechanisms by which high-dose estrogen therapy produces anabolic skeletal effects in postmenopausal women: role of locally produced growth factors.

@article{Bord2001MechanismsBW,
  title={Mechanisms by which high-dose estrogen therapy produces anabolic skeletal effects in postmenopausal women: role of locally produced growth factors.},
  author={Sharyn Bord and Sian R. Beavan and Deborah C Ireland and Alan Horner and Juliet E Compston},
  journal={Bone},
  year={2001},
  volume={29 3},
  pages={216-22}
}
Conventional hormone replacement therapy acts primarily by preserving bone, but cannot restore lost bone in women with established osteoporosis. Studies in rodents have shown that high doses of estrogens have anabolic skeletal effects, and recent observations in a group of women treated long term with high doses of estrogen indicated that similar effects occur in humans. This study examines the hypothesis that locally produced growth factors, including transforming growth factor-beta (TGF-beta… CONTINUE READING