Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR).

@article{Basbaum2002MechanismsBW,
  title={Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR).},
  author={Carol B. Basbaum and Daizong Li and Erin Gensch and Marianne Gallup and Hassan Lemjabbar},
  journal={Novartis Foundation symposium},
  year={2002},
  volume={248},
  pages={171-6; discussion 176-80, 277-82}
}
Mucin, the major macromolecular component of mucus, is generally considered to be a protective substance. When overproduced in a variety of lung diseases, however, mucin gives rise to clinical problems such as airway obstruction and recurrent infection. Our approach to identifying drug targets for the control of mucin overproduction is the analysis of cellular signalling pathways linking stimuli in the diseased lung to mucin transcription. Here we show that mucin transcription in response to… CONTINUE READING
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