Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

@article{Lyssenko2007MechanismsBW,
  title={Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.},
  author={V. Lyssenko and R. Lupi and P. Marchetti and Silvia Del Guerra and M. Orho-Melander and P. Almgren and M. Sj{\"o}gren and C. Ling and K. Eriksson and {\AA}saLinda Lethagen and R. Mancarella and G. Berglund and T. Tuomi and P. Nilsson and S. Del Prato and L. Groop},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 8},
  pages={
          2155-63
        }
}
Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up to 22 years were genotyped for 3 SNPs (rs7903146, rs12255372, and rs10885406) in TCF7L2, and a subset… Expand
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