Corpus ID: 29600223

Mechanisms by which amphetamine and desipramine inhibit the metaraminol-induced release of norepinephrine from sympathetic nerve endings in rat heart.

  title={Mechanisms by which amphetamine and desipramine inhibit the metaraminol-induced release of norepinephrine from sympathetic nerve endings in rat heart.},
  author={F. Leitz},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={173 1},
  • F. Leitz
  • Published 1 May 1970
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The net influx of metaraminol into sympathetic nerve endings of rat ventricle slices as well as the resultant efflux of norepinephrine (NE) is a function of the metaraminol concentration in the incubation fluid and reaches a maximum at a concentration of about 400 ng/ml. Amphetamine in low concentrations (0.4 ) reduces the efflux of NE and the uptake of metaraminol to the same extent, indicating that amphetamine interferes with the metaraminol-induced release of NE only by reducing the uptake… Expand
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  • Naunyn-Schmiedeberg's Archives of Pharmacology
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