Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins.

@article{Helt2003MechanismsBW,
  title={Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins.},
  author={A M Helt and Denise A. Galloway},
  journal={Carcinogenesis},
  year={2003},
  volume={24 2},
  pages={159-69}
}
Small DNA tumor viruses have evolved different mechanisms to abrogate the function of the retinoblastoma tumor suppressor (pRb). Studies of these viruses have been invaluable in uncovering the central role of the Rb family of pocket proteins in cell cycle control. While the molecular mechanisms by which the viral oncoproteins inactivate the Rb family are still being elucidated, it is clear that targeting of this family is required both for viral replication and for virus-induced transformation… CONTINUE READING

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