Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins.

  title={Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins.},
  author={Anna-Marija Helt and D. Galloway},
  volume={24 2},
  • Anna-Marija Helt, D. Galloway
  • Published 2003
  • Medicine, Biology
  • Carcinogenesis
  • Small DNA tumor viruses have evolved different mechanisms to abrogate the function of the retinoblastoma tumor suppressor (pRb). Studies of these viruses have been invaluable in uncovering the central role of the Rb family of pocket proteins in cell cycle control. While the molecular mechanisms by which the viral oncoproteins inactivate the Rb family are still being elucidated, it is clear that targeting of this family is required both for viral replication and for virus-induced transformation… CONTINUE READING
    Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins
    • 155
    • Highly Influenced
    • PDF
    Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
    • 328
    • PDF
    Regulation of the retinoblastoma proteins by the human herpesviruses
    • 64
    • PDF
    Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus
    • 51
    • Highly Influenced
    • PDF
    The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation
    • 105
    • PDF


    Publications referenced by this paper.
    The regulation of E2F by pRB-family proteins.
    • 2,282
    • PDF