• DOI:10.15406/EMIJ.2017.04.00107
• Corpus ID: 62796950

Mechanisms by Which the Ketogenic Diet Reverses Obesity and Diabetes

@article{Moreno2017MechanismsBW,
  title={Mechanisms by Which the Ketogenic Diet Reverses Obesity and Diabetes},
  author={Cesar L. Moreno and Michal M. Poplawski and Jason Mastaitis and Charles V. Mobbs},
  journal={Endocrinology\&Metabolism International Journal},
  year={2017},
  volume={4}
}

• Cesar L. Moreno, M. Poplawski, +1 author C. Mobbs
• Published 16 June 2017
• Medicine
• Endocrinology&Metabolism International Journal

Since the beginning of the 20th century, when low-carbohydrate diets were first implemented to treat Type 1 diabetes, the role of dietary composition in regulating glucose homeostasis and, increasingly, energy balance, has been the subject of great interest to both biomedical researchers and, increasingly, to the public. In fairly extreme circumstances (e.g., Type 1 diabetes untreated with insulin) low-carbohydrate diets (which are generally high-fat diets) can be useful to reduce blood glucose, but since the advent of insulin therapy, and increasing appreciation of the cardiovascular consequences of hyperlipidemia, clinical practice has dramatically favored highcarbohydrate, low-fat diets for diabetes (especially Type 2 diabetes, largely associated with obesity). This clinical advice, at the time, seemed fairly radical. In a famous treatise, “The Physiology of Taste” published in 1825, Brillat-Savarin, argue that consumption of “natural” diets (e.g., meat and vegetables) promote health, whereas “cultivated” diet (e.g., derived from rice and wheat) increasingly led to deterioration of health associated with affluence.