Mechanisms by Which the Ketogenic Diet Reverses Obesity and Diabetes

@article{Moreno2017MechanismsBW,
  title={Mechanisms by Which the Ketogenic Diet Reverses Obesity and Diabetes},
  author={Cesar L. Moreno and Michal M. Poplawski and Jason Mastaitis and Charles V. Mobbs},
  journal={Endocrinology\&Metabolism International Journal},
  year={2017},
  volume={4}
}
Since the beginning of the 20th century, when low-carbohydrate diets were first implemented to treat Type 1 diabetes, the role of dietary composition in regulating glucose homeostasis and, increasingly, energy balance, has been the subject of great interest to both biomedical researchers and, increasingly, to the public. In fairly extreme circumstances (e.g., Type 1 diabetes untreated with insulin) low-carbohydrate diets (which are generally high-fat diets) can be useful to reduce blood glucose… 

The Effects of A Short Period of A Ketogenic Diet on Blood Biochemistry and Immunological Status in Overweight Thai Subjects

The data revealed that short-term KD in this study decreased participants’ physical body compositions and blood glucose levels, and the immune status after KD proved the immunomodulation effect of KD.

The Pathophysiological Role of Diet in Non-Communicable Disease Etiology

Research confirms diet to be both a risk factor (unhealthful diet) and at the same time protective for NCDs and further epidemiological studies should emphasize the assessment of Health outcomes based on the quantity, frequency, concentration, synergistic interactions of various dietary nutrients.

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This study shows the beneficial effects of ketogenic diet in obese diabetic subjects following its long-term administration and demonstrates that in addition to its therapeutic value, low carbohydrate diet is safe to use for a longer period of time in obesity diabetic subjects.

A high-fat, ketogenic diet induces a unique metabolic state in mice.

Data indicate that KD induces a unique metabolic state congruous with weight loss, consistent with increased energy expenditure seen in animals fed KD vs. those on C and CR.

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In mice of normal weight and with diet-induced obesity, a high-fat, low-carbohydrate ketogenic diet (KD) causes weight loss, reduced circulating glucose and lipids, and dramatic changes in hepatic

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