Mechanisms behind COX-1 and COX-2 inhibition of tumor growth in vivo.

  title={Mechanisms behind COX-1 and COX-2 inhibition of tumor growth in vivo.},
  author={Hans Axelsson and Christina L{\"o}nnroth and Marianne Andersson and Kent G Lundholm},
  journal={International journal of oncology},
  volume={37 5},
Non-steroidal anti-inflammatory drugs (NSAIDs) attenuate tumor net growth in clinical and experimental cancer. Evaluations in cell culture experiments have implied involvement of growth factor and G-protein related signaling pathways to explain decreased proliferation, angiogenesis, increased cell adhesion and apoptosis. Sparse information is however available from studies on growing tumors in vivo. The aim of the present study was to map alterations in selected signal proteins in relation to… CONTINUE READING


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