Mechanisms and targets of deep brain stimulation in movement disorders

  title={Mechanisms and targets of deep brain stimulation in movement disorders},
  author={M. Johnson and S. Miocinovic and C. McIntyre and J. Vitek},
  • M. Johnson, S. Miocinovic, +1 author J. Vitek
  • Published 2011
  • Medicine
  • Neurotherapeutics
  • SummaryChronic electrical stimulation of the brain, known as deep brain stimulation (DBS), has become a preferred surgical treatment for medication-refractory movement disorders. Despite its remarkable clinical success, the therapeutic mechanisms of DBS are still not completely understood, limiting opportunities to improve treatment efficacy and simplify selection of stimulation parameters. This review addresses three questions essential to understanding the mechanisms of DBS. 1) How does DBS… CONTINUE READING
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    Publications referenced by this paper.
    Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition.
    • 652
    • Open Access
    Mechanisms of deep brain stimulation: Excitation or inhibition
    • 410
    Deep brain stimulation creates an informational lesion of the stimulated nucleus
    • 260
    Deep brain stimulation for Parkinson's disease: disrupting the disruption
    • 309
    • Highly Influential
    Subthalamic nucleus stimulation in Parkinson disease
    • 37
    Normalizing motor-related brain activity
    • 120
    • Open Access
    Subthalamic nucleus stimulation: improvements in outcome with reprogramming.
    • 105
    • Open Access