Mechanisms and targets of deep brain stimulation in movement disorders

@article{Johnson2008MechanismsAT,
  title={Mechanisms and targets of deep brain stimulation in movement disorders},
  author={Matthew D. Johnson and Svjetlana Miocinovic and Cameron C. McIntyre and Jerrold L. Vitek},
  journal={Neurotherapeutics},
  year={2008},
  volume={5},
  pages={294-308}
}
Chronic electrical stimulation of the brain, known as deep brain stimulation (DBS), has become a preferred surgical treatment for medication-refractory movement disorders. Despite its remarkable clinical success, the therapeutic mechanisms of DBS are still not completely understood, limiting opportunities to improve treatment efficacy and simplify selection of stimulation parameters. This review addresses three questions essential to understanding the mechanisms of DBS. 1) How does DBS affect… CONTINUE READING
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