Mechanisms and risk of chemically induced aneuploidy in mammalian germ cells.

@article{Pacchierotti2006MechanismsAR,
  title={Mechanisms and risk of chemically induced aneuploidy in mammalian germ cells.},
  author={Francesca Pacchierotti and Roberto Ranaldi},
  journal={Current pharmaceutical design},
  year={2006},
  volume={12 12},
  pages={
          1489-504
        }
}
Aneuploidy is a pathological condition that affects 35% of human spontaneous abortions and 0.3% of livebirths. In spite of the increasing knowledge about molecular mechanisms of meiosis and chromosome segregation, maternal age remains the only ascertained aetiological factor. Genetically modified mouse models have been produced that show increased incidence… CONTINUE READING