Mechanisms and regulation of endothelial VEGF receptor signalling

@article{Simons2016MechanismsAR,
  title={Mechanisms and regulation of endothelial VEGF receptor signalling},
  author={M. Simons and E. Gordon and L. Claesson-Welsh},
  journal={Nature Reviews Molecular Cell Biology},
  year={2016},
  volume={17},
  pages={611-625}
}
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely required to balance the formation of new blood vessels with the maintenance and remodelling of existing ones, during development and in adult tissues. Recent advances have greatly expanded our understanding of the tight and multi-level regulation of VEGFR2 signalling, which is the primary focus of this Review. Important insights have been gained into the regulatory roles of VEGFR-interacting proteins (such as… Expand
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