Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death.

@article{Lang2015MechanismsAP,
  title={Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death.},
  author={Elisabeth Lang and Florian Lang},
  journal={Seminars in cell & developmental biology},
  year={2015},
  volume={39},
  pages={35-42}
}
Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling, is stimulated by Ca(2+) entry through Ca(2+)-permeable, PGE2-activated cation channels, by ceramide, caspases, calpain, complement, hyperosmotic shock, energy depletion, oxidative stress, and deranged activity of several kinases (e.g. AMPK, GK, PAK2, CK1α, JAK3, PKC, p38-MAPK). Eryptosis is triggered by intoxication, malignancy, hepatic failure, diabetes, chronic renal insufficiency… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 189 references

Inhibition of Ca(2+)-dependent K+ trans- Please cite this article in press

  • C Brugnara, L de Franceschi, SL. Alper
  • Semin Cell Dev Biol
  • 2015
2 Excerpts

Conju - gated bilirubin triggers anemia by inducing erythrocyte death

  • PA Lang, M Schenck, JP Nicolay, JU Becker, DS Kempe, A Lupescu
  • Hepatology
  • 2014

Similar Papers

Loading similar papers…