Mechanisms and molecules that control growth cone guidance.

  title={Mechanisms and molecules that control growth cone guidance.},
  author={Corey S. Goodman},
  journal={Annual review of neuroscience},
Neuronal growth cones traverse long distances along appropriate pathways to find their correct targets. This review presents an overview of the mechanisms and molecules that control these events. Secreted and cell surface ligands in the growth cone's environment bind to receptors on the growth cone's surface, trigger second-messenger signals, and lead to appropriate steering decisions. Growth cones appear to be guided by at least four different mechanisms: contact-mediated attraction… CONTINUE READING
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