Mechanisms and molecules in motor neuron specification and axon pathfinding.

  title={Mechanisms and molecules in motor neuron specification and axon pathfinding.},
  author={Joseph Jacob and Anja Hacker and Sarah Guthrie},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={23 7},
The vertebrate nervous system performs the most complex functions of any organ system. This feat is mediated by dedicated assemblies of neurons that must be precisely connected to one another and to peripheral tissues during embryonic development. Motor neurons, which innervate muscle and regulate autonomic functions, form an integral part of this neural circuitry. The first part of this review describes the remarkable progress in our understanding of motor neuron differentiation, which is… CONTINUE READING

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