Mechanisms and modulation of macrophage activation.

@article{Nathan1991MechanismsAM,
  title={Mechanisms and modulation of macrophage activation.},
  author={Carl Nathan},
  journal={Behring Institute Mitteilungen},
  year={1991},
  volume={88},
  pages={200-7}
}
  • Carl Nathan
  • Published 1991 in Behring Institute Mitteilungen
In the two decades following the discovery that macrophages can be activated by cytokines, there have been four major advances in our understanding of this phenomenon: (i) the identification of two biochemically defined, cytokine-inducible antimicrobial pathways, the enzymatic generation of superoxide and the enzymatic generation of nitric oxide; (ii) the identification of individual cytokines of known amino acid sequence capable of inducing these antimicrobial pathways and enhancing macrophage… CONTINUE READING

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