Mechanisms and mediators in hepatic necrosis

  title={Mechanisms and mediators in hepatic necrosis},
  author={Prof. Dr. Karl Decker},
  journal={Gastroenterologia Japonica},
Necrotic processes may be restricted to individual cell types of the liver or afflict several liver cells sequentially. Noxious agents may induce necrobiosis by different mechanisms of injury. In many instances, however, similar or identical terminal processes are involved, e.g. accumulation of Ca2+ in cytosol or mitochondria, termination of nucleic acid and protein syntheses or membrane damage. Apoptosis may also be a relevant feature of hepatic necrosis. Inhibition of mRNA synthesis and… CONTINUE READING


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