Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase.

@article{Santos2009MechanismsAI,
  title={Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase.},
  author={C{\'e}lio X. C. Santos and Leonardo Yuji Tanaka and Jo{\~a}o Wosniak and Francisco Rafael Martins Laurindo},
  journal={Antioxidants & redox signaling},
  year={2009},
  volume={11 10},
  pages={2409-27}
}
Cellular mechanisms governing redox homeostasis likely involve their integration with other stresses. Endoplasmic reticulum (ER) stress triggers complex adaptive or proapoptotic signaling defined as the unfolded protein response (UPR), involved in several pathophysiological processes. Since protein folding is highly redox-dependent, convergence between ER stress and oxidative stress has attracted interest. Evidence suggests that ROS production and oxidative stress are not only coincidental to… CONTINUE READING
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