Mechanisms and implications of hypoalbuminemia in head-injured patients.

  title={Mechanisms and implications of hypoalbuminemia in head-injured patients.},
  author={C J Mcclain and Bernhard Hennig and L G Ott and Simeon E. Goldblum and Anne B. Young},
  journal={Journal of neurosurgery},
  volume={69 3},
Severely head-injured patients are hypermetabolic/hypercatabolic and exhibit many aspects of the postinjury acute-phase response. These patients have hypoalbuminemia, hypozincemia, hypoferremia, hypercupria, fever, and increased synthesis of acute-phase proteins such as ceruloplasmin and higher C-reactive protein levels. It has been suggested that increased interleukin-1 (IL-1) in the ventricular fluid may be responsible, at least in part, for these metabolic abnormalities. In the present study… CONTINUE READING


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