Mechanisms and dynamics of heterochromatin formation during mammalian development: closed paths and open questions.

@article{Fadloun2013MechanismsAD,
  title={Mechanisms and dynamics of heterochromatin formation during mammalian development: closed paths and open questions.},
  author={Anas Fadloun and André Eid and Maria-Elena Torres-Padilla},
  journal={Current topics in developmental biology},
  year={2013},
  volume={104},
  pages={
          1-45
        }
}
Early embryonic development in mammals is characterized by major changes in the components of the chromatin and its remodeling. The embryonic chromatin and the nuclear organization in the mouse preimplantation embryo display particular features that are dramatically different from somatic cells. These include the highly specific organization of the pericentromeric heterochromatin within the nucleus and the suggested lack of conventional heterochromatin. We postulate that the plasticity of the… CONTINUE READING

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