Mechanisms and clinical significance of cell volume regulation.

  title={Mechanisms and clinical significance of cell volume regulation.},
  author={Siegfried Waldegger and Susi Steuer and Teut Risler and August Heidland and Giovambattista Capasso and Shaul G. Massry and Florian Lang},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={13 4},
A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic… CONTINUE READING

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