Mechanisms and abuse liability of the anti-histamine dimenhydrinate

@article{Halpert2002MechanismsAA,
  title={Mechanisms and abuse liability of the anti-histamine dimenhydrinate},
  author={Alison G Halpert and Mary C. Olmstead and Richard J. Beninger},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2002},
  volume={26},
  pages={61-67}
}
The over-the-counter anti-emetic dimenhydrinate (DMH) (Gravol or Dramamine) has been reported to be abused for non-medicinal purposes. Street drug users abuse DMH for the acute effects of euphoric sensations and hallucinations, while psychiatric patients abuse DMH for its anxiolytic or anti-cholinergic effects. DMH is an H(1) histamine receptor antagonist, but it interacts either directly or indirectly with other neurotransimitter systems, including those using acetylcholine, serotonin… Expand
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