Mechanisms and Significance of Cell Volume Regulation

@article{Lang2007MechanismsAS,
  title={Mechanisms and Significance of Cell Volume Regulation},
  author={Florian Lang},
  journal={Journal of the American College of Nutrition},
  year={2007},
  volume={26},
  pages={613S - 623S}
}
  • F. Lang
  • Published 9 October 2006
  • Biology
  • Journal of the American College of Nutrition
Survival of human and animal cells requires avoidance of excessive alterations of cell volume. The osmolarity amassed by cellular accumulation of organic substances must be compensated by lowering cytosolic ion concentrations. The Na+/K+ ATPase extrudes Na+ in exchange for K+, which can permeate the cell membrane through K+ channels. K+ exit generates a cell-negative potential difference across the cell membrane, driving the exit of anions such as Cl−. The low cytosolic Cl− concentrations… 
Physiology of cell volume regulation in vertebrates.
TLDR
Current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species are reviewed.
Channels and Volume Changes in the Life and Death of the Cell
TLDR
Findings showing that multimers derived from LRRC8A (leucine-rich repeat containing 8A) gene are structural components of the volume-regulated Cl– channel (VRAC), and the intriguing possibility that different heteromer combinations comprise channels with different intrinsic properties that allow permeation of the heterogenous group of molecules acting as organic osmolytes are discussed.
Osmosensitivity through the PIP2 availability: just add water
  • N. Gamper
  • Biology
    The Journal of physiology
  • 2010
TLDR
An interesting new mechanism which may prove to be one of the general principles of ion channel (or any plasma membrane protein) osmosensitivity was put forward by Piron et al. (2010), which closely resembled the regulation of IKs by the availability of plasma membrane phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2).
Basolateral ion transporters involved in colonic epithelial electrolyte absorption, anion secretion and cellular homeostasis
TLDR
Recently gathered information on the molecular identity, function and regulation of the involved basolateral transport systems in native tissue are summarized and how these findings can help to integrate these systems into the transport function and the cellular homoeostasis of colonic epithelial cells are discussed.
Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death
TLDR
This series of review articles addresses the question how cell death is induced or protected with using ubiquitously expressed ion channels such as swelling-activated anion channels, acid-activatedAnion channels and several types of TRP cation channels including TRPM2 and TRPM7.
Cell volume regulation: physiology and pathophysiology
TLDR
Recent major developments in the field are summarized, and significant progress has been made with respect to the nature of the sensors, transducers and effectors that convert a change in cell volume into a physiological response.
Swelling-Induced Ca2+ Influx and K+ Efflux in American Alligator Erythrocytes
TLDR
Results show that cell swelling activated a K+ permeable pathway via a Ca2+-dependent mechanism, and this process mediated K+ loss during RVD.
Phosphorylation and Activation of the Plasma Membrane Na+/H+ Exchanger (NHE1) during Osmotic Cell Shrinkage
TLDR
The first reported evidence of increased NHE1 phosphorylation during OCS in any vertebrate cell type is reported, suggesting that activation of atNHE1 involves multiple phosphorylated and/or dephosphorylation events.
The role of Ca 2+ and K + in the regulatory volume decrease mechanism of Alligator mississippiensis erythrocytes
TLDR
This study focused on the specific RVD signaling pathways in Alligator mississippiensis erythrocytes and found that Ca 2+ likely entered the cell through an ATP-gated purinoreceptor, thereby leading to K + efflux through a quinine-sensitive channel, and the efflux of K + was a rate limiting step during volume recovery.
...
...

References

SHOWING 1-10 OF 80 REFERENCES
The Diversity of Volume Regulatory Mechanisms
TLDR
The diversity of cellVolume regulatory mechanisms allows the cells to defend the constancy of cell volume against a myriad of challenges with relatively little impairment of cellular function.
Membrane mechanisms and intracellular signalling in cell volume regulation.
Ion Channels in Cell Proliferation and Apoptotic Cell Death
TLDR
Significant further experimental effort is required to fully understand the complex interplay between ion channels, cell proliferation and apoptosis, as specific ion channel blockers may abrogate both fundamental cellular mechanisms, depending on cell type, regulatory environment and condition of the cell.
Functional significance of cell volume regulatory mechanisms.
TLDR
Cell volume may be considered a second message in the transmission of hormonal signals, and alterations of cell volume and volume regulatory mechanisms participate in a wide variety of cellular functions including epithelial transport, metabolism, excitation, hormone release, migration, cell proliferation, and cell death.
Regulation of the Cellular Content of the Organic Osmolyte Taurine in Mammalian Cells
TLDR
Using Ehrlich ascites tumor cells, NIH3T3 mouse fibroblasts and HeLa cells as biological systems, it is revealed that phospholipase A2-mediated mobilization of arachidonic acid fromospholipids and subsequent oxidation of the fatty acid via lipoxygenase systems to potent eicosanoids are essential elements in the signaling cascade that is activated by cell swelling and leads to release of osmolytes.
Mechanisms Sensing and Modulating Signals Arising From Cell Swelling
TLDR
The intracellular mechanisms underlying the sensing of cell volume perturbations and the activation of volume compensatory processes, commonly summarized as regulatory volume decrease (RVD), are revealed.
Sensors and signal transduction pathways in vertebrate cell volume regulation.
TLDR
This review highlights recent advances in the understanding of the complex sequences of events by which acute cell volume perturbation alters the activity of osmolyte transport proteins in cells from vertebrate organisms.
Cell volume-sensitive chloride channels: phenotypic properties and molecular identity.
  • Y. Okada
  • Biology
    Contributions to nephrology
  • 2006
TLDR
There is a paucity of the molecular information of the VSOR Cl(-) channel, suggesting that its outer vestibule and pore are larger and smaller, respectively, than the sizes of ATP and glibenclamide.
Cell volume homeostasis: ionic and nonionic mechanisms. The sodium pump in the emergence of animal cells.
  • W. Stein
  • Biology
    International review of cytology
  • 2002
Calcium signaling in cell volume regulation.
TLDR
It is likely that the RVD mechanism is a highly complex process involving events and biochemical pathways throughout the cell rather than events simply localized to the inner face of the plasma membrane.
...
...