Mechanisms and Significance of Cell Volume Regulation

  title={Mechanisms and Significance of Cell Volume Regulation},
  author={Florian Lang},
  journal={Journal of the American College of Nutrition},
  pages={613S - 623S}
  • F. Lang
  • Published 9 October 2006
  • Biology
  • Journal of the American College of Nutrition
Survival of human and animal cells requires avoidance of excessive alterations of cell volume. The osmolarity amassed by cellular accumulation of organic substances must be compensated by lowering cytosolic ion concentrations. The Na+/K+ ATPase extrudes Na+ in exchange for K+, which can permeate the cell membrane through K+ channels. K+ exit generates a cell-negative potential difference across the cell membrane, driving the exit of anions such as Cl−. The low cytosolic Cl− concentrations… 
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