Mechanisms Underlying Vasorelaxation Induced in Rat Aorta by Galetin 3,6-Dimethyl Ether, a Flavonoid from Piptadenia stipulacea (Benth.) Ducke

  title={Mechanisms Underlying Vasorelaxation Induced in Rat Aorta by Galetin 3,6-Dimethyl Ether, a Flavonoid from Piptadenia stipulacea (Benth.) Ducke},
  author={Cib{\'e}rio Landim Mac{\^e}do and Luiz Henrique C Vasconcelos and Ana Carolina de C. Correia and Italo Rossi Roseno Martins and Daysianne Pereira de Lira and B{\'a}rbara V. de O. Santos and Fabiana de A. Cavalcante and Bagn{\'o}lia Ara{\'u}jo da Silva},
  pages={19678 - 19695}
In this study, we investigated the relaxant action of galetin 3,6-dimethyl ether (FGAL) on rat aorta. The flavonoid relaxed both PMA‑ and phenylephrine (Phe)-induced contractions (pD2 = 5.36 ± 0.11 and 4.17 ± 0.10, respectively), suggesting the involvement of PKC and Phe pathways or α1 adrenergic receptor blockade. FGAL inhibited and rightward shifted Phe-induced cumulative concentration‑response curves, indicating a noncompetitive antagonism of α1 adrenergic receptors. The flavonoid was more… 

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Spasmolytic effect of galetin 3,6-dimethyl ether, a flavonoid obtained from Piptadenia stipulacea (Benth) Ducke.

Galetin 3,6-dimethyl ether (FGAL) is a flavonoid isolated from the aerial components of Piptadenia stipulacea (Benth) Ducke that shows a non-selective spasmolytic effect on each of the smooth muscle preparations the authors have tested, but with a greater effect on those from the rat aorta.

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Histamine-induced relaxation in pulmonary artery of normotensive and hypertensive rats: relative contribution of prostanoids, nitric oxide and hyperpolarization.

  • J. Török
  • Biology, Medicine
    Physiological research
  • 2000
The aim of this study was to determine the relative contribution of nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF) and prostanoids in histamine-induced relaxation of isolated