Mechanisms Underlying Plk1 Polo-Box Domain-Mediated Biological Processes and Their Physiological Significance

@inproceedings{Lee2014MechanismsUP,
  title={Mechanisms Underlying Plk1 Polo-Box Domain-Mediated Biological Processes and Their Physiological Significance},
  author={Kyung S Lee and Jung-Eun · Lee Park and Young Hwi Kang and Tae-Sung Kim and Jeong Kyu Bang},
  booktitle={Molecules and cells},
  year={2014}
}
Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key regulator of various cell cycle events that are critical for proper M-phase progression. The polobox domain (PBD) present in Plk1's C-terminal noncatalytic region has been shown to play a central role in targeting the N-terminal kinase domain of Plk1 to specific subcellular locations. Subsequent studies reveal that PBD binds to a phosphorylated motif generated by one of the two mechanisms-self-priming by Plk1 itself or… CONTINUE READING

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