Mechanisms Underlying Endothelin-1 Level Elevations Caused by Excessive Fluoride Exposure

  title={Mechanisms Underlying Endothelin-1 Level Elevations Caused by Excessive Fluoride Exposure},
  author={Liyan Sun and Yanhui Gao and Wei Zhang and Xiaona Liu and Bingyun Li and Xiaohui Cui and Dianjun Sun},
  journal={Cellular Physiology and Biochemistry},
  pages={861 - 873}
  • Liyan Sun, Yanhui Gao, +4 authors Dianjun Sun
  • Published in
    Cellular Physiology and…
  • Biology, Medicine
  • Objective: To explore the mechanisms underlying endothelin-1 (ET-1) elevations induced by excessive fluoride exposure. Methods: We measured serum and bone fluoride ion content and plasma ET-1 levels and compared these parameters among different groups in an animal model. We also observed morphological changes in the aorta and endothelium of rabbits. In cell experiments, human umbilical vein endothelial cells (HUVECs) were treated with varying concentrations of NaF for 24h, with or without 10 µM… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv


    Publications citing this paper.


    Publications referenced by this paper.

    An assessment of the relationship between excess fluoride intake from drinking water and essential hypertension in adults residing in fluoride endemic areas

    • H Liu, Y Gao, +3 authors D Sun
    • Sci Total Environ
    • 2013