Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ

@article{Schomerus2005MechanismsRM,
  title={Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ},
  author={C. Schomerus and H. Korf},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1057}
}
The day/night rhythm in melatonin production is a characteristic feature in vertebrate physiology. This hormonal signal reliably reflects the environmental light conditions and is independent of behavioral aspects. In all mammalian species, melatonin production is regulated by norepinephrine, which is released from sympathetic nerve fibers exclusively at night. Norepinephrine elevates the intracellular cAMP concentration via β‐adrenergic receptors and activates the cAMP‐dependent protein kinase… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.
TLDR
The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates. Expand
Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland.
TLDR
It is discovered that expression of the AA-NAT gene in the rat pineal gland is essentially turned off during the day and turned on at night, resulting in a more than 150-fold rhythm. Expand
Transcription Factors in Neuroendocrine Regulation: Rhythmic Changes in pCREB and ICER Levels Frame Melatonin Synthesis
TLDR
It is shown with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP–responsive element–binding protein (pCREB), and a transcriptionAL inhibitor, inducible cAMP early repressor (ICER). Expand
Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription.
TLDR
To compare the transcriptional impact of norepinephrine with that of other neurotransmitters on melatonin synthesis, ICER protein levels in pinealocytes and, in parallel, hormone secretion are determined. Expand
Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland
TLDR
To identify proteins that regulate light–dark variations in pineal function, a subtractive hybridization technique based on the polymerase chain reaction (PCR) was used to isolate rat pineal gland messages that are differentially expressed by day and night. Expand
Selective Adrenergic/Cyclic AMP‐Dependent Switch‐Off of Proteasomal Proteolysis Alone Switches on Neural Signal Transduction
TLDR
Findings show that tightly regulated control of proteasomal proteolysis of a specific protein alone can play a pivotal role in neural regulation. Expand
Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli
TLDR
The study reveals that discrete differences in pineal signal transduction exist between the cow and rodent, and emphasizes the potential importance that the analysis of ungulate pinealocytes may play in understanding regulation of pineal melatonin biosynthesis in primates and man. Expand
The Pineal Organ, Its Hormone Melatonin, and the Photoneuroendocrine System
TLDR
The functional significance of the melatonin-synthesizing pineal organ as an important component of the photoneuroendocrine system is confirmed and the importance of this organ as a model to study signal transduction mechanisms both in photoreceptors and in neuroendocrine cells is stressed. Expand
Methionine Adenosyltransferase:Adrenergic-cAMP Mechanism Regulates a Daily Rhythm in Pineal Expression*
TLDR
It is found that pineal MAT2A mRNA and the protein it encodes, MAT II, also increase at night, suggesting that the increase inMAT activity is caused by an increase in MAT II gene products, and underscores the importance that MAT plays in melatonin biogenesis. Expand
Transcription factor dynamics and neuroendocrine signalling in the mouse pineal gland: a comparative analysis of melatonin‐deficient C57BL mice and melatonin‐proficient C3H mice
TLDR
It is concluded that the commonly used C57BL mouse is not completely melatonin‐deficient and that this melatonin-deficiency does not affect molecular details involved in regulating transcriptional events of melatonin synthesis. Expand
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