Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ

  title={Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ},
  author={Christof Schomerus and Horst-Werner Korf},
  journal={Annals of the New York Academy of Sciences},
  • C. Schomerus, H. Korf
  • Published 1 December 2005
  • Biology
  • Annals of the New York Academy of Sciences
The day/night rhythm in melatonin production is a characteristic feature in vertebrate physiology. This hormonal signal reliably reflects the environmental light conditions and is independent of behavioral aspects. In all mammalian species, melatonin production is regulated by norepinephrine, which is released from sympathetic nerve fibers exclusively at night. Norepinephrine elevates the intracellular cAMP concentration via β‐adrenergic receptors and activates the cAMP‐dependent protein kinase… 
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