Mechanisms Involving Ang II and MAPK/ERK1/2 Signaling Pathways Underlie Cardiac and Renal Alterations during Chronic Undernutrition

@inproceedings{Silva2014MechanismsIA,
  title={Mechanisms Involving Ang II and MAPK/ERK1/2 Signaling Pathways Underlie Cardiac and Renal Alterations during Chronic Undernutrition},
  author={Paulo Andr{\'e} da Silva and Gustavo Monnerat-Cahli and Amaury Pereira-Ac{\'a}cio and Ricardo Luzardo and Luzia da Silva Sampaio and Marcia A. Luna-Leite and Lucienne da Silva Lara and M Einicker-Lamas and Rog{\'e}rio Panizzutti and Caroline Madeira and Leucio Duarte Vieira-Filho and Carmen de Castro-Chaves and Valdilene S. Ribeiro and Ana Durce O Paix{\~a}o and Emiliano Hor{\'a}cio Medei and Adalberto Vieyra},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Several studies have correlated protein restriction associated with other nutritional deficiencies with the development of cardiovascular and renal diseases. The driving hypothesis for this study was that Ang II signaling pathways in the heart and kidney are affected by chronic protein, mineral and vitamin restriction. METHODOLOGY/PRINCIPAL FINDINGS Wistar rats aged 90 days were fed from weaning with either a control or a deficient diet that mimics those used in impoverished… CONTINUE READING