Mechanisms Generating Diversity in Glucocorticoid Receptor Signaling

  title={Mechanisms Generating Diversity in Glucocorticoid Receptor Signaling},
  author={Javier R Revollo and John A. Cidlowski},
  journal={Annals of the New York Academy of Sciences},
Glucocorticoids regulate diverse biological processes throughout the body via the glucocorticoid receptor (GR). Ligand‐bound GR translocates into the nucleus and can elicit changes in gene expression by direct contact with the DNA or by protein–protein interactions with other transcription factors. The GR can also mediate rapid nongenomic signaling events initiated in the cytoplasm. In this chapter, we review the biological and physiological implications of glucocorticoids, the GR, and many of… 

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FasL is the first gene described whose repression by GR is mediated by sterical occlusion of NFkB DNA binding, and represents an additional mechanism for the GR‐NFkB mutual antagonism.

Mechanisms of glucocorticoid signalling.

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling*

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Potentiation of glucocorticoid receptor transcriptional activity by sumoylation.

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