Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings

@article{Gerwyn2017MechanismsEM,
  title={Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings},
  author={M Jones Gerwyn and Michael Maes},
  journal={Current Rheumatology Reports},
  year={2017},
  volume={19},
  pages={1-10}
}
Purpose of ReviewHere, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat shock protein production and a range of metabolic abnormalities.Recent FindingsSeveral studies published in the last few years have highlighted the existence of chronic O&NS, inflammation, impaired mitochondrial function… 
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