Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings

  title={Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings},
  author={M Jones Gerwyn and Michael Maes},
  journal={Current Rheumatology Reports},
Purpose of ReviewHere, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat shock protein production and a range of metabolic abnormalities.Recent FindingsSeveral studies published in the last few years have highlighted the existence of chronic O&NS, inflammation, impaired mitochondrial function… 

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Central basis of muscle fatigue in chronic fatigue syndrome

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Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

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Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review.

The literature review provides level B evidence for an altered immune response to exercise in patients with CFS, including an alteration in the immune cells' gene expression profile.

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