Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

  title={Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1},
  author={Zhidan Wu and Pere B. Puigserver and Ulf Andersson and Chen-Yu Zhang and Guillaume Adelmant and Vamsi K. Mootha and Amy Troy and Saverio Cinti and Bradford Lowell and Richard C. Scarpulla and Bruce M. Spiegelman},
Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of these factors into a program responsive to the environment is not understood. We show here that PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation… CONTINUE READING
Highly Influential
This paper has highly influenced 130 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
1,363 Citations
45 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 1,363 extracted citations


Publications referenced by this paper.
Showing 1-10 of 45 references

stained with lead citrate and examined with a transmission electron microscopy Philips CM10 (Eindhoven, The Netherlands)

  • J. S. Flier, B. B. Lowell
  • leak. Nat. Genet
  • 1997
Highly Influential
4 Excerpts

Dilated cardiomyopathy and atrioventricular embryogenesis in mice

  • C. R. Kahn, D. A. Clayton, G. S. Barsh, P. Thoren, N. G. Larsson
  • Nat . Genet .
  • 1999

Role of nonex - chondrial DNA gene expression

  • J. A. Levine, N. L. Eberhardt, M. D. Jensen
  • Nat . Genet .
  • 1999

conduction blocks induced by heart-specific inactivation

  • J. A. mitoLevine, N. L. Eberhardt, M. D. Jensen
  • Nat. Genet
  • 1999

Similar Papers

Loading similar papers…