Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

@article{Wu1999MechanismsCM,
  title={Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1},
  author={Zhidan Wu and Pere B. Puigserver and Ulf Andersson and Chen-Yu Zhang and Guillaume Adelmant and Vamsi K. Mootha and Amy Troy and Saverio Cinti and Bradford Lowell and Richard C. Scarpulla and Bruce M. Spiegelman},
  journal={Cell},
  year={1999},
  volume={98},
  pages={115-124}
}
Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of these factors into a program responsive to the environment is not understood. We show here that PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation… CONTINUE READING
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