Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development
@article{Shook2003MechanismsMA, title={Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development}, author={David R. Shook and Ray Keller}, journal={Mechanisms of Development}, year={2003}, volume={120}, pages={1351-1383} }
548 Citations
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To more fully understand mechanisms underlying the EMT process, and for better knowledge of the embryonic defects related to this process, it would be useful to study the substrates on which EMT cells move during embryo development, focusing on a few different embryonic systems.
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An overview of the molecular regulation of the EMT process during embryo development, focusing on chick and mouse gastrulation and neural crest development, and how further advances in the field will rely on in vivo dynamic imaging of the cellular events of EMT.
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This chapter describes the key principles of EMT and characterize EMT in the primitive streak during chicken gastrulation and indicates that epiblast/BM interaction requires basally localized RhoA activity, and CLASP- and dystroglycan-mediated cortical microtubule anchoring, the disruption of which causes BM degradation during Gastrulation EMT.
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It is proposed that the time course and extent of EMT do not depend merely on the identity of the EMT transcriptional regulators and their cellular effectors but rather on the combination of molecular players recruited and on the possible coordination of E MT with other cellular processes.
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The induction of EMT in response to TGF-β is discussed, and the underlying signaling and transcription mechanisms are focused on.
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The cellular, molecular, and microenvironmental mechanisms used by TGF- β to mediate its stimulation of EMT in normal and malignant cells are reviewed.
Compartmentalized morphogenesis in epithelia: From cell to tissue shape
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Moving from apical to basal, a review of compartmentalized cellular rearrangements underlying tissue remodeling in Drosophila and compare them with those found in other organisms is reviewed.
References
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