Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development

@article{Shook2003MechanismsMA,
  title={Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development},
  author={D. Shook and R. Keller},
  journal={Mechanisms of Development},
  year={2003},
  volume={120},
  pages={1351-1383}
}
Epithelial-mesenchymal transitions (EMTs) are an important mechanism for reorganizing germ layers and tissues during embryonic development. They have both a morphogenic function in shaping the embryo and a patterning function in bringing about new juxtapositions of tissues, which allow further inductive patterning events to occur [Genesis 28 (2000) 23]. Whereas the mechanics of EMT in cultured cells is relatively well understood [reviewed in Biochem. Pharmacol. 60 (2000) 1091; Cell 105 (2001… Expand
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