Mechanisms, impact and management of pain in rheumatoid arthritis

  title={Mechanisms, impact and management of pain in rheumatoid arthritis},
  author={David Walsh and Daniel F. McWilliams},
  journal={Nature Reviews Rheumatology},
People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that often persists despite optimal control of inflammatory disease. RA pain arises from multiple mechanisms, involving inflammation, peripheral and central pain processing and, with disease progression, structural change within the joint. Consequently, RA pain has a wide range of characteristics—constant or intermittent, localized or widespread—and is often associated with psychological distress and… CONTINUE READING
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