Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study.

@article{Guccione2001MechanismUM,
  title={Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study.},
  author={Julius M. Guccione and Scott M Moonly and Pavlos Moustakidis and Kevin D. Costa and Michael J. Moulton and Mark B. Ratcliffe and Michael K. Pasque},
  journal={The Annals of thoracic surgery},
  year={2001},
  volume={71 2},
  pages={654-62}
}
BACKGROUND The global left ventricular dysfunction characteristic of left ventricular aneurysm is associated with muscle fiber stretching in the adjacent noninfarcted (border zone) region during isovolumic systole. The mechanism of this regional dysfunction is poorly understood. METHODS An anteroapical transmural myocardial infarct was created by coronary arterial ligation in an adult Dorset sheep and was allowed to mature into left ventricular aneurysm for 10 weeks. The animal was imaged… CONTINUE READING
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