Mechanism underlying histamine-induced intracellular Ca2+ movement in PC3 human prostate cancer cells.

@article{Lee2001MechanismUH,
  title={Mechanism underlying histamine-induced intracellular Ca2+ movement in PC3 human prostate cancer cells.},
  author={Kuochen Lee and Han Tung Chang and Katherine J Chou and K-W. Tang and Jing Wang and Yi Kai Lo and J. K. Huang and Wei Chih Chen and Warren Su and Yi Ping. Law and Chung Ren Jan},
  journal={Pharmacological research},
  year={2001},
  volume={44 6},
  pages={
          547-52
        }
}
The effect of histamine on intracellular free Ca2+ levels ([Ca2+]i) in PC3 human prostate cancer cells and the underlying mechanism were evaluated using fura-2 as a Ca2+ dye. Histamine at concentrations between 0.1 and 50 microM increased [Ca2+]i in a concentration-dependent manner with an EC50 value of 1 microM. The [Ca2+]i response comprised an initial rise and a slow decay, which returned to baseline within 3 min. Extracellular Ca2+ removal inhibited 50% of the [Ca2+]i signal. In the absence… CONTINUE READING
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