Mechanism underling enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice 1

@inproceedings{Bing2003MechanismUE,
  title={Mechanism underling enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice 1},
  author={Shen Bing and Ye Chun-ling and Ye Kai-he and Liu Jian-jun and Sun Peng and Jiang Jia-hua},
  year={2003}
}
AIM: To investigate the mechanism of the enhanced endothelium-dependent vasodilatation in thoracic aorta of the early stage streptozotocin (STZ)-induced diabetic C57BL/6J mice. METHODS: Radioimmunity was used to detect the metabolite of prostaglandin I2 (PGI2), 6-keto-prostaglandin F1α (6-keto-PGF1α), in the blood serum. Vascular muscle tension and phenylephrine (PE)-induced rhythmic activity in the isolated thoracic aorta of mice were also compared. RESULTS: 6-Keto-PGF1α in the serum was… CONTINUE READING

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