Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease.

@article{Sato2005MechanismOV,
  title={Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease.},
  author={Atsushi Sato and Ken Terata and Hiroto Miura and Kazuyoshi Toyama and Fausto R. Loberiza and Ossama A Hatoum and Takashi Saito and Ichiro Sakuma and David D. Gutterman},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 4},
  pages={
          H1633-40
        }
}
  • A. Sato, K. Terata, D. Gutterman
  • Published 1 April 2005
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
Adenosine is a key myocardial metabolite that elicits coronary vasodilation in a variety of pathophysiological conditions. We examined the mechanism of adenosine-induced vasodilation in coronary arterioles from patients with heart disease. Human coronary arterioles (HCAs) were dissected from pieces of the atrial appendage obtained at the time of cardiac surgery and cannulated for the measurement of internal diameter with videomicroscopy. Adenosine-induced vasodilation was not inhibited by… 

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References

SHOWING 1-10 OF 64 REFERENCES
Adenosine A2A Receptors Mediate Coronary Microvascular Dilation to Adenosine: Role of Nitric Oxide and ATP-Sensitive Potassium Channels
TLDR
The results suggest that the dilation of coronary arterioles to adenosine is mediated predominantly by A 2A receptors, and the role of nitric oxide and ATP-sensitive potassium channels in this vasodilatory response is investigated.
Mechanism of thrombin-induced vasodilation in human coronary arterioles.
TLDR
Thrombin-induced dilation in human arterioles is independent of G(i)-protein activation and NO release, however, Thromb dilation is endothelium dependent, is maintained on consecutive applications, and involves activation of K(+) channels.
Effect of ATP-Sensitive Potassium Channel Inhibition on Resting Coronary Vascular Responses in Humans
TLDR
Vascular KATP channels are involved in the maintenance of basal coronary tone but may not be essential to adenosine-induced coronary hyperemia in humans.
Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation.
TLDR
The hypothesis that endogenous adenosine is involved in regulation of human coronary tone is supported.
Flow-Induced Dilation of Human Coronary Arterioles: Important Role of Ca2+-Activated K+ Channels
TLDR
It is concluded that shear stress induces endothelium-dependent vasodilation, hyperpolarizing VSMCs through opening Ca2+-activated K+ channels in human coronary arterioles, consistent with a role in FID of the human coronary microcirculation.
Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: contribution of nitric oxide and Ca2+-activated K+ channels.
TLDR
Dilation to BK was associated with greater membrane hyperpolarization than dilation to sodium nitroprusside (SNP) for similar degrees of dilation, which suggests a role for K+ channel activation in regulating human coronary arteriolar tone.
Adenosine mediates relaxation of human small resistance‐like coronary arteries via A2B receptors
TLDR
The results suggest that A2B receptors mediate relaxation to adenosine in human small coronary arteries which is independent of NO but dependent in part on a K+‐sensitive mechanism.
Coronary dilator actions of adenosine and CO2 in experimental diabetes.
TLDR
It is concluded that increases [H+] has a potent direct coronary dilator action in both control and diabetic lambs and enhances responsiveness to adenosine.
Inhibition of cAMP mediated relaxation in rat coronary vessels by block of Ca++ activated K+ channels.
TLDR
The results show that rat coronary resistance arteries possess significant myogenic tone and modulation of Kca channels plays a major role in cAMP mediated relaxation.
...
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