Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease.

@article{Sato2005MechanismOV,
  title={Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease.},
  author={Atsushi Sato and Ken Terata and Hiroto Miura and Kazuyoshi Toyama and Fausto R. Loberiza and Ossama A Hatoum and Takashi Saito and Ichiro Sakuma and David D. Gutterman},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 4},
  pages={
          H1633-40
        }
}
  • A. SatoK. Terata D. Gutterman
  • Published 1 April 2005
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
Adenosine is a key myocardial metabolite that elicits coronary vasodilation in a variety of pathophysiological conditions. We examined the mechanism of adenosine-induced vasodilation in coronary arterioles from patients with heart disease. Human coronary arterioles (HCAs) were dissected from pieces of the atrial appendage obtained at the time of cardiac surgery and cannulated for the measurement of internal diameter with videomicroscopy. Adenosine-induced vasodilation was not inhibited by… 

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