Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells.

Abstract

Cisplatin (CDDP) and its analogues are widely used for the treatment of a variety of human solid tumors. However, the molecular mechanism of its action remains to be understood. Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis and is upregulated in many human cancers. In this study we demonstrated that CDDP-inhibited VEGF… (More)

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@article{Zhong2007MechanismOV, title={Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells.}, author={Xiao-song Zhong and Ling-zhi Liu and Heath Devin Skinner and Zongxian Cao and Min Ding and Bing-Hua Jiang}, journal={Biochemical and biophysical research communications}, year={2007}, volume={358 1}, pages={92-8} }