[Mechanism of vascular calcification].


Vascular calcification is clinically important in the development of cardiovascular disease. It has been suggested that apoptosis and chondro/osteogenic differentiation of vascular smooth muscle cells (VSMC) play important roles in the initiation and progression of vascular calcification. During the process of vascular calcification, growth arrest-specific gene 6 (Gas6) mediated-survival pathway is downregulated in VSMC, leading to apoptosis. Chondro/osteogenic differentiation regulated by transcription factors such as core binding factor alpha1 (Cbfa1) or msh homeo box homolog 2 (Msx2), promotes VSMC calcification. It is clear that vascular calcification is an active process regulated by various factors including Gas6, Cbfa1, or Msx2.

Cite this paper

@article{Son2007MechanismOV, title={[Mechanism of vascular calcification].}, author={Bo-Kyung Son and Masahiro Akishita}, journal={Clinical calcium}, year={2007}, volume={17 3}, pages={319-24} }