Corpus ID: 23299168

Mechanism of uptake of dihydroergotamine by isolated rat hepatocytes: effect of troleandomycin.

@article{Dumont1985MechanismOU,
  title={Mechanism of uptake of dihydroergotamine by isolated rat hepatocytes: effect of troleandomycin.},
  author={Micheline Dumont and G de Cou{\"e}t and J F Le Bigot and Serge Erlinger},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={234 1},
  pages={
          239-43
        }
}
  • Micheline Dumont, G de Couët, +1 author Serge Erlinger
  • Published 1985
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The mechanism of uptake of dihydroergotamine (DHE) was studied in isolated rat hepatocytes and the effect of troleandomycin on DHE uptake was examined. The uptake was linear for 75 sec and reached an equilibrium at 5 min with an intracellular/extracellular concentration ratio of approximately 65. The initial velocity of uptake was linearly related to the concentration of DHE in the extracellular medium with a diffusion constant of 127 pmol X min-1 X mg of protein-1 X microM-1. Metabolic… CONTINUE READING

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