Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.

@article{Tanabe2003MechanismOU,
  title={Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.},
  author={Masako Tanabe and Mitsue Kurita-Taniguchi and Kaoru Takeuchi and Makoto Takeda and Minoru Ayata and Hisashi Ogura and Misako Matsumoto and Tsukasa Seya},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={311 1},
  pages={39-48}
}
PolyI:C, a synthetic double-stranded (ds)RNA, and viruses act on cells to induce IFN-beta which is a key molecule for anti-viral response. Although dsRNA is a virus-specific signature and a ligand for human Toll-like receptor 3 (TLR3), largely uncharacterized multiple pathways associate virus-mediated IFN-beta induction. Here, we demonstrated that laboratory-adapted but not wild-type strains of measles virus (MV) up-regulated TLR3 expression both in dendritic cells and epithelial cell line A549… CONTINUE READING