Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer.

@article{Trosko2001MechanismOU,
  title={Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer.},
  author={James Edward Trosko and Chia Chien Chang},
  journal={Mutation research},
  year={2001},
  volume={480-481},
  pages={219-29}
}
To develop a strategy for efficacious intervention in order to prevent or treat various cancers, one must understand the basic mechanism(s) by which various anticancer dietary factors prevent or reverse the tumor promotion or progression phases. Carcinogenesis is a multistage, multimechanism process, involving the irreversible alteration of a stem cell (the "initiation" phase), followed by the clonal proliferation of the initiated stem cell (the "promotion" phase), from which the acquisition of… CONTINUE READING

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