Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.

@article{Chen2016MechanismOU,
  title={Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.},
  author={Gai-Ge Chen and Jin-Bin Yan and X Wang and Ming-zhi Zheng and Jian-ping Jiang and Xin-mei Zhou and Bin Cai and Yue-liang Shen},
  journal={Molecular medicine reports},
  year={2016},
  volume={14 2},
  pages={1857-64}
}
In the present study, the alterations in uncoupling protein 2 (UCP2) expression following hypothermic preservation in rat hearts were investigated. Isolated rat hearts were preserved in Celsior solution for 3‑12 h followed by 60 min of reperfusion. The cardiac function was evaluated using the Langendorff perfusion system. UCP2 and silent mating type information regulation 2 homolog 1 (SIRT1) proteins were detected by western blot analysis. The ATP production and mitochondrial reactive oxygen… CONTINUE READING
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