Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53.

@article{Athar2000MechanismOU,
  title={Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53.},
  author={Mohammad Athar and Arianna Kim and Noor Hidayah Tauhid Ahmad and Hasan Mukhtar and Jillian Gautier and David R. Bickers},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={277 1},
  pages={
          107-11
        }
}
The ultraviolet B (UVB) portion (280-320 nm) of solar radiation is considered to be a major etiologic factor in human skin cancer and is a known cause of extensive DNA damage. In this study, we observed that UVB exposure of immortalized epidermal keratinocytes (HaCat cells) harboring mutant p53 leads to G(2)/M cell cycle arrest in both asynchronously growing and synchronized cells in a dose dependent manner. Following UVB exposure (200 mJ/cm(2)), we observed a threefold increase in G(2)/M… CONTINUE READING
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