Corpus ID: 7976337

Mechanism of tubular uptake on human growth hormone in perfused rat kidneys.

  title={Mechanism of tubular uptake on human growth hormone in perfused rat kidneys.},
  author={S. Kau and T. Maack},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={236 3},
  • S. Kau, T. Maack
  • Published 1986
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The mechanism of tubular uptake of labeled human growth hormone ([125I]hGH), a low molecular weight protein (approximate 21,5000 daltons), was studied in isolated perfused rat kidneys. Fractional reabsorption (FR) of [125I]hGH was decreased from 94 to 77% over a period of 80 min as perfusate oncotic pressure was lowered by reducing the albumin concentration from 7.5 to 2.5 g/100ml, whereas greater reductions in fractional sodium (delta 35%) and fluid reabsorption (delta 42%) occurred… CONTINUE READING
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