Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier.

@article{Beloqui2013MechanismOT,
  title={Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier.},
  author={Ana Beloqui and Mar{\'i}a {\'A}ngeles Solin{\'i}s and Alicia Rodr{\'i}guez Gasc{\'o}n and Ana del Pozo-Rodr{\'i}guez and Anne des Rieux and V{\'e}ronique Pr{\'e}at},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2013},
  volume={166 2},
  pages={115-23}
}
The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers (NLCs) as a tool to enhance the oral bioavailability of poorly soluble compounds using saquinavir (SQV), a BCS class IV drug and P-gp substrate as a model drug, and (ii) to study NLC transport mechanisms across the intestinal barrier. Three different NLC formulations were evaluated. SQV transport across Caco-2 monolayers was enhanced up to 3.5-fold by NLCs compared to SQV suspension. M cells did not… CONTINUE READING
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