Mechanism of translation of the hepadnaviral polymerase (P) gene.

  title={Mechanism of translation of the hepadnaviral polymerase (P) gene.},
  author={L J Chang and Donald E Ganem and H. E. Varmus},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 13},
Unlike many other reverse transcriptase genes, the polymerase (P) gene of the hepatitis B viruses is expressed by translational initiation from its own AUG codon rather than by ribosomal frameshifting during translation of the overlapping core gene (C). To explore the mechanism of its translation, we have fused the P gene of duck hepatitis B virus to the bacterial lacZ gene at a point 3' to the C-P overlap; this allows detection of the products of P translation with antisera to the lacZ-encoded… CONTINUE READING


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